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C. difficile infection (CDI) is a costly and increasing burden on the healthcare systems of many 11 developed countries due to the high rates of nosocomial infections. Despite the availability of 12 several antibiotics with high response rates, effective treatment is hampered by recurrent 13 infections. One potential mechanism for recurrence is the existence of C. difficile biofilms in the 14 gut which persist through the course of antibiotics. In this review, we describe current 15 developments in understanding the molecular mechanisms by which C. difficile biofilms form 16 and are stabilized through extracellular biomolecular interactions.more » « less
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